基于SERS的光学纳米生物传感器用于检测阿尔茨海默氏症
Feng Gao1,2, Fang Li1,2, Jianhao Wang1,2
1Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Biosensors
|September 27, 2023
概括
表面增强的拉曼散射 (SERS) 生物传感器为早期阿尔茨海默病 (AD) 诊断提供了一种敏感的,非侵入性的方法. 本综述探讨了用于检测AD生物标志物的SERS技术,为精准医学铺平了道路.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 分析化学 分析化学
背景情况:
- 阿尔茨海默病 (AD) 是复杂病理性痴呆的主要原因,阻碍了早期诊断和治疗.
- 目前阿尔茨海默病的诊断方法面临的挑战是由于疾病的异质性和晚期检测.
- 对于早期发现阿尔茨海默氏病的敏感,非侵入性工具有着至关重要的需求.
研究的目的:
- 审查基于表面增强的拉曼散射 (SERS) 生物传感器用于早期阿尔茨海默病诊断的应用.
- 突出SERS技术在利用纳米材料提高生物标志物检测的潜力.
- 讨论开发用于阿尔茨海默病标志物的SERS传感器的未来方向和挑战.
主要方法:
- 基于SERS的生物传感器技术的审查,针对阿尔茨海默病的生物标志物.
- 对SERS传感器中使用的纳米材料进行分析,以提高检测灵敏度.
- 讨论生物标志物驱动的诊断和精准医学对阿尔茨海默病的方法.
主要成果:
- SERS生物传感器在检测AD生物标志物方面表现出高灵敏度和非侵入性能力.
- 各种纳米材料增强了光学性能,以获得卓越的检测性能.
- 对于生物标志物驱动的临床诊断和个性化医疗,SERS传感器显示出有前途.
结论:
- 基于SERS的生物传感器代表了早期和准确诊断阿尔茨海默病的有希望的途径.
- 纳米材料的整合显著提高了SERS传感器用于AD标志物检测的性能.
- 对SERS技术的进一步研究对于克服挑战和推进AD诊断至关重要.
相关概念视频
Alzheimer's Disease: Overview
513
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
513
Alzheimer's Disease: Treatment
212
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
212


