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相关概念视频

RNA Editing02:23

RNA Editing

9.0K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.0K
Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

10.7K
The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...
10.7K

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相关实验视频

Updated: Jul 15, 2025

A Nonsequencing Approach for the Rapid Detection of RNA Editing
08:50

A Nonsequencing Approach for the Rapid Detection of RNA Editing

Published on: April 21, 2022

2.6K

基准测试RNA编辑检测工具检测工具

David Rodríguez Morales1, Sarah Rennie1, Shizuka Uchida2

  • 1Department of Biology, University of Copenhagen, DK-2200 Copenhagen N, Denmark.

Biotech (Basel (Switzerland))
|September 27, 2023
PubMed
概括
此摘要是机器生成的。

经转录学研究正在增长,RNA编辑是其中的一个重点. 这项研究对从RNA测序数据中检测RNA编辑位点 (RES) 的生物信息工具进行了基准测试,以指导研究人员.

关键词:
编辑RNA的RNA编辑有关RNA测序的RNA测序数据库就是数据库.标志性转录组学 标志性转录组学工具 工具 工具 工具 工具

更多相关视频

RNA Catalyst as a Reporter for Screening Drugs against RNA Editing in Trypanosomes
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RNA Catalyst as a Reporter for Screening Drugs against RNA Editing in Trypanosomes

Published on: July 22, 2014

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Targeted RNA Sequencing Assay to Characterize Gene Expression and Genomic Alterations
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Targeted RNA Sequencing Assay to Characterize Gene Expression and Genomic Alterations

Published on: August 4, 2016

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相关实验视频

Last Updated: Jul 15, 2025

A Nonsequencing Approach for the Rapid Detection of RNA Editing
08:50

A Nonsequencing Approach for the Rapid Detection of RNA Editing

Published on: April 21, 2022

2.6K
RNA Catalyst as a Reporter for Screening Drugs against RNA Editing in Trypanosomes
09:19

RNA Catalyst as a Reporter for Screening Drugs against RNA Editing in Trypanosomes

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Targeted RNA Sequencing Assay to Characterize Gene Expression and Genomic Alterations
11:52

Targeted RNA Sequencing Assay to Characterize Gene Expression and Genomic Alterations

Published on: August 4, 2016

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科学领域:

  • 分子生物学分子生物学
  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.

背景情况:

  • 目前存在超过170种RNA修饰,创造了表体转录学领域.
  • RNA编辑,特别是氨酸转化为氨酸 (A-to-I) 和氨酸转化为氨酸 (C-to-U),在哺乳动物转录组中很常见.
  • 从RNA测序 (RNA-seq) 数据中可以检测到RNA编辑,从而提供了对表观转录组的见解.

研究的目的:

  • 从RNA-seq数据中对检测RNA编辑位点 (RES) 的生物信息工具进行基准测试.
  • 提供可用于 RES 检测的可用工具的全面比较.
  • 为未来的研究提供选择合适工具的建议.

主要方法:

  • 针对可再生能源检测而设计的各种生物信息工具的比较分析.
  • 使用先前发布的RNA-seq数据集进行性能评估.
  • 基于既定标准对工具性能进行比较分析.

主要成果:

  • 每个生物信息学工具都有不同的优点和缺点.
  • 在分析RNA-seq数据时,观察到工具之间的性能差异.
  • 该研究提供了每个工具的详细性能概述.

结论:

  • 选择适合RES检测的生物信息工具对于研究人员和临床医生来说至关重要.
  • 这项比较研究有助于选择最适合特定研究需求的工具.
  • 提供了建议,以促进有效利用RNA-seq数据进行表观转录组分析.