与血液学异常相关的SARS-CoV-2病理影响
Shama1, Asif Mahmood1,2, Shahid Mehmood3
1Department of Microbiology, School of Medicine, Jiangsu University, Zhenjiang 212013, China.
Current issues in molecular biology
|September 27, 2023
概括
冠状病毒2 (SARS-CoV-2) 导致COVID-19,导致血液学异常和血栓形成. 早期抗凝血治疗对于管理COVID-19并发症和改善患者结果至关重要.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 流行病已经造成了重大的全球健康问题.
- COVID-19 感染会影响多个器官系统,特别是血液系统,导致严重的并发症.
- 血液学异常,包括血小板缺血和淋巴缺血,与COVID-19患者的不良结果有关.
研究的目的:
- 要突出与COVID-19相关的血液学并发症.
- 强调早期识别和管理COVID-19患者的血栓事件的重要性.
- 讨论抗凝剂在缓解COVID-19相关发病率和死亡率方面的作用.
主要方法:
- 关于COVID-19病理生理学和血液学表现的当前文献的综述.
- 关于COVID-19中血栓事件和凝血异常的临床数据的分析.
- 在严重的COVID-19病例中检查生物标志物 (LDH,D-二次体,费里丁,CRP) 概况.
主要成果:
- COVID-19可以引发细胞因子风暴和血管内血栓,导致动脉和静脉血栓.
- 常见的血液学发现包括血小板缺血,淋巴缺血和中性恋,与预后不佳相关.
- 像LDH,D-二聚体,费里丁和CRP这样的生物标志物的升高表明了严重的COVID-19和不利的结果.
结论:
- 及时识别和治疗抗凝剂对于管理COVID-19相关的凝血障碍至关重要.
- 了解病理生理学,包括细胞因子风暴和血栓形成,是有效的COVID-19患者管理的关键.
- 预防性抗凝剂在预防严重并发症和降低COVID-19死亡率方面发挥着至关重要的作用.
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