肠道微生物组和代谢综合征 - - 如何操纵它可能会影响代谢相关脂肪肝疾病 (MAFLD)
Stephen D H Malnick1,2, Sheral Ohayon Michael1,2
1Department of Internal Medicine C, Kaplan Medical Center, Rehovot 76100, Israel.
Current issues in molecular biology
|September 27, 2023
概括
与代谢相关的脂肪肝疾病 (MAFLD) 与肠道微生物组的变化有关. 便微生物移植 (FMT) 显示出对调节肠道微生物群来治疗MAFLD的承诺.
科学领域:
- 胃肠病学和肝病学
- 微生物学 微生物学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 代谢相关的脂肪肝疾病 (MAFLD) 是一个日益严重的全球健康问题,主要是由肥胖引起的.
- 肠道微生物组 (IM) 显著影响宿主代谢,肠道屏障功能和代谢综合征 (MS) 的发展.
- 肠道内脏的变化与MAFLD和MS的发病和进展有关.
研究的目的:
- 审查肠道微生物组在代谢综合征和MAFLD发展中的作用.
- 讨论便微生物移植 (FMT) 的当前应用和潜力,以调节MAFLD中的IM.
主要方法:
- 这篇叙事综述综合了有关IM,MS,MAFLD和FMT的现有文献.
- 讨论了研究IM失调和代谢疾病之间的关系的研究的主要发现.
- 检查了关于FMT作为MAFLD治疗策略的当前证据.
主要成果:
- IM在新陈代谢调节和肠道健康方面发挥着至关重要的作用,失生症有助于MAFLD和MS.
- 生活方式的修改,MAFLD治疗的基石,也影响IM.
- 复发性*Clostridioides difficile*感染的已知治疗方法FMT正在研究其改变IM和治疗MAFLD的潜力.
结论:
- 肠道微生物组是MAFLD和相关代谢功能障碍的发展和进展的关键因素.
- 便微生物移植是针对肠道微生物群的MAFLD治疗干预的有希望的途径.
- 需要进一步的研究来确定FMT在MAFLD治疗中的有效性和安全性.
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