与艾滋病毒感染的病患者:地理和时间变化的系统审查和元分析
Aravind P Gandhi1, Bijaya K Padhi2, Mokanpally Sandeep3
1Department of Community Medicine, ESIC Medical College & Hospital, Sanathnagar, Hyderabad 500038, India.
Epidemiologia (Basel, Switzerland)
|September 27, 2023
概括
这项元分析发现,有41%的患有 (mpox) 的人也患有人类免疫缺陷病毒 (HIV). 这凸显了在受影响人群中检测两种感染的重要性.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 麻疹 (mpox) 和人类免疫缺陷病毒 (HIV) 是全球重要的健康问题.
- 同时感染mopox和HIV可能会影响疾病的表现和结果.
- 了解mpox患者中艾滋病毒的流行率对于公共卫生战略至关重要.
研究的目的:
- 在全球范围内估计艾滋病毒感染在被诊断为mopox的个体中的综合流行率.
- 综合现有关于这两种病毒感染同时发生的证据.
主要方法:
- 在七个主要数据库中进行了系统的搜索,搜索到2023年1月4日之前发表的相关人体研究.
- 使用随机效应元分析,由于预期的异质性,将患病率估计汇总起来.
- 研究质量使用国家心脏,肺和血液研究所 (NHLBI) 工具进行评估.
主要成果:
- 分析包括29项研究,在mpox患者中,艾滋病毒的综合流行率为41% (95%CI,35-48).
- 患病率在地理上有所不同,北美 (52%) 和欧洲 (41%) 的患病率较高,而尼日利亚和非洲 (21%) 的患病率较高.
- 所有纳入的研究都被评为相当或质量良好.
结论:
- 很大一部分mpox患者同时感染艾滋病毒,特别是在西部地区.
- 在mopox的临床管理中,应考虑同时感染HIV的可能性.
- 公共卫生干预措施应专注于识别和管理共感染个体,包括接触者追踪和测试.
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