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肠道微生物群对睡眠相关表型的因果影响:一个双样本的孟德尔随机化研究

Min Yue^1,2, Chuandi Jin^1,2, Xin Jiang^1,2

¹Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

|September 27, 2023

概括

这项研究使用了门德尔的随机化来研究肠道细菌与睡眠之间的因果关系. 某些肠道微生物影响睡眠时间,打和失眠,为新的睡眠障碍治疗提供了潜在的目标.

科学领域:

微生物组研究微生物组研究
睡眠科学睡眠科学
遗传学遗传学是一个

背景情况:

越来越多的证据将肠道微生物群组成与睡眠表型联系起来.
肠道微生物群和睡眠之间的因果关系尚不清楚.

研究的目的:

研究肠道微生物群对睡眠特征的因果关系.
为了确定与睡眠表型因果相关的特定肠道微生物种群.

主要方法:

使用了两个样本的门德尔随机化 (MR) 方法.
从事全基因组关联研究,对来自多个大队伍的肠道微生物群 (n=18,340) 和睡眠表型的总结统计.
进行了灵敏度分析,包括水平形,异质性,MR 施泰格方向性,留出一个,以及反向MR分析,以确保稳定性.

主要成果:

确定了*Anaerofilum*属对早晨清醒的负面因果作用.
发现Enterobacteriales序列和Enterobacteriaceae家族与"晚上的人"有关.
与睡眠时间 (例如, *Lachnospiraceae UCG004*, *Odoribacter*用于更长的睡眠时间),打风险 (*Ruminococcus torques*, *Senegalimassilia*) 和失眠风险 (Selenomonadales, Negativicutes) 相关的特定肠道种群.

结论:

确立了肠道微生物群在影响各种睡眠特征中的因果作用.
确定了特定的肠道微生物种群作为因果风险或时型,睡眠时间,打和失眠的保护因素.
研究结果表明,对于睡眠障碍,基于微生物群的干预措施有潜力.

关键词:

门德尔的随机化研究.不正常的睡眠模式.年代型年代型年代型年代型我们的肠道微生物群.睡眠质量睡眠质量

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