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对于温度敏感的水凝作为调制递送乙氨基的载体

Snežana Ilić-Stojanović¹, Ljubiša Nikolić¹, Vesna Nikolić¹

¹Faculty of Technology, University of Niš, Bulevar oslobodjenja 124, 16000 Leskovac, Serbia.

Gels (Basel, Switzerland)

|September 27, 2023

概括

由N-异烯酸胺和2-基烯酸甲酸盐制成的温度敏感的水凝显示出药物输送的潜力. 这些p ((NIPA/HPMA) 水凝有效地加载和释放了乙氨基,为频繁的口服提供了有希望的替代品.

科学领域:

聚合物科学与工程聚合物科学与工程
生物材料科学生物材料科学
药物输送系统药物输送系统

背景情况:

乙氨基的口服,一个常见的NSAID,带来了像过量服用这样的风险,需要频繁的剂量 (每天最多四次).
对温度敏感的水凝为控制和延长药物释放提供了一个潜在的解决方案,旨在每天服用一次.
聚N-异烯酸胺-co-2-基烯酸甲酸盐 (p(NIPA/HPMA)) 共聚合物正在探索它们在先进的药物输送应用中的适用性.

研究的目的:

为了合成和表征温度敏感的p ((NIPA/HPMA) 水凝.
评估合成的水凝的热,形态和膨胀特性.
评估这些水凝作为乙氨基药物递送系统的潜力.

主要方法:

聚合N-异 propyl 烯胺和2-基 propyl 甲酸盐,形成温度敏感的水凝.
使用差分扫描热量测量 (DSC),扫描电子显微镜 (SEM) 和里埃变换红外光谱 (FTIR) 的表征.
在模拟的胃肠道条件下,通过高性能液体染色学 (HPLC) 分析的乙胺烯加载和释放研究.

主要成果:

p ((NIPA/HPMA) 水凝表现出特有的热过渡 (化和玻璃过渡) 和温度依赖的膨胀行为.
FTIR分析证实了乙氨基和水凝基质之间的键,SEM显示了水凝孔内的药物存在.
装载效率超过92%,并且在24小时内释放了90-99%的装载氨基,并确定了动力参数.

结论:

合成的对温度敏感的p ((NIPA/HPMA) 水凝显示出适用于药物输送应用的有利特性.
水凝有效地加载并释放了乙氨基,表明了调制,延长药物管理的潜力.
需要进一步的研究,以优化这些水凝的实用性,每天一次的药物输送系统.

关键词:

2-基基甲基酸盐二基基甲基酸盐美国国家安全委员会 DSC.N-异 propyl 烯胺的使用情况乙氨基的使用方法毒品运输商毒品运输商这种水凝是水凝.调节药物释放的药物释放方式

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