可自的基于白的冷凝具有不妥协的性能
Kairui Duan1,2, Nabila Mehwish2, Mengdie Xu2
1Postgraduate Training Base Alliance, Wenzhou Medical University, Wenzhou 325011, China.
Gels (Basel, Switzerland)
|September 27, 2023
概括
自式牛血清白甲基烯基 (BSAMA) 冰凝在灭菌后保持其特性. 这些BSAMA冷凝显示了增强的降解和有效的灭菌,使它们适合生物医学应用.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 生物医学工程 生物医学工程
背景情况:
- 常规的水凝在自封化过程中经常降解,限制了它们在无菌生物医学应用中的使用.
- 开发稳定的消毒水凝对于安全有效的医疗器械和治疗应用至关重要.
研究的目的:
- 为了研究自闭塞对牛血清白甲基 (BSAMA) 冰凝的物理,机械和生物特性的影响.
- 为了评估与BSAMA冷凝的其他方法相比,自封式灭菌的灭菌效果.
主要方法:
- BSAMA冷凝是在3,5和10%的蛋白质度下制备的.
- 进行了自处理,以评估形状,结构,机械性能 (Young的模量) 和降解率的变化.
- 细胞活力,药物释放概况和血液溶解活性在自封之前和之后进行了评估.
- 对抗细菌污染的灭菌有效性被比较到自封,紫外线和乙醇治疗.
主要成果:
- 在自化后,BSAMA冷凝保留了其粗体形状,孔隙结构和蛋白质二次结构.
- 的模量与低度自封式BSAMA冷凝相似,但在10%度下更高.
- 自化BSAMA冷凝表现出长时间的降解.
- 细胞活力,药物释放和血液溶解行为在自封化前后保持一致.
- 与紫外线和乙醇治疗相比,自闭塞证明了优越的细菌灭菌.
结论:
- 在高温灭菌后,自式BSAMA冷凝保持了关键性质.
- 这些冷凝提供了长时间的降解特征和有效的灭菌,超过紫外线和乙醇方法.
- BSAMA冷凝是各种生物医学应用的有希望的候选者,需要无菌,坚固的水凝材料.
相关概念视频
01:31Plasticizers
Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
01:30Superplasticizers
Superplasticizers are advanced admixtures that enhance the workability of concrete by lowering the water content without compromising the strength of the material. These substances are highly effective water reducers, improving concrete flow, making it easier to work with, and enabling concrete to reach inaccessible areas or densely reinforced sections without mechanical vibration. The key components in superplasticizers are either sulfonated melamine or naphthalene formaldehyde condensates,...
01:27Cold Weather Concreting
When freshly poured concrete is exposed to freezing temperatures before it has set, the water within the concrete can freeze. This expansion disrupts the setting process, delays chemical reactions necessary for hardening, and increases the volume of pores within the hardened concrete, which weakens its overall structure. If the concrete manages to reach an appreciable strength before it freezes, the damage can be somewhat mitigated.
To counteract the negative impacts of cold weather, ensuring...
To counteract the negative impacts of cold weather, ensuring...
01:27Frost Action on Concrete
Concrete structures in cold climates, such as those along roadsides, can retain moisture. This moisture makes them susceptible to frost-related damage when temperatures fall below freezing. Adding moisture worsens the damage during temperature fluctuations, leading to repeated freezing and thawing. De-icing salts, spread over these structures to melt ice, add to the freeze-thaw cycle, and draw even more moisture into the concrete.
This freeze-thaw cycle primarily causes surface scaling, where...
This freeze-thaw cycle primarily causes surface scaling, where...
01:29Frost Resistant Concrete
Concrete's susceptibility to frost damage during freeze-thaw cycles demands strategic measures to enhance its frost resistance. Employing techniques like air entrainment, adjusting the water-cement ratio, proper curing, and selecting appropriate aggregates are essential.
Introducing microscopic air bubbles into the concrete mix through air entrainment creates small voids that accommodate ice expansion, thereby reducing internal pressures and preventing cracking. The optimal amount of entrained...
Introducing microscopic air bubbles into the concrete mix through air entrainment creates small voids that accommodate ice expansion, thereby reducing internal pressures and preventing cracking. The optimal amount of entrained...
01:14Design Example: Managing Concrete Workability
This example deals with managing the workability of concrete for a raft foundation project under hot weather conditions. Workability is crucial for ensuring the concrete is easy to place, compact, and finish. In this scenario, a slump test — a common method to measure the workability of fresh concrete — initially indicated low workability. This was attributed to the rapid water loss from the concrete mix, exacerbated by the high temperatures causing the course aggregates to heat up.
To address...
To address...