合成和表征Alginate凝珠与嵌入的天岩结构作为载体的疏水性黄素
Gianluca Ciarleglio1, Federica Cinti1, Elisa Toto1
1Department of Chemical Engineering Materials Environment, Sapienza University of Rome, Via del Castro Laurenziano 7, 00161 Rome, Italy.
Gels (Basel, Switzerland)
|September 27, 2023
概括
含有多孔热 (Z5A) 的酸盐珠有效封装黄素,增强其传递. 酸盐涂层提高了稳定性,使得这些pH响应的珠子有望用于向的脂性药物输送.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 纳米技术 纳米技术
背景情况:
- 黄是一种来自黄的天然化合物,具有强大的抗氧化和抗炎性质,但生物可用性差.
- 像黄素这样的疏水药物需要有效的载体来提高溶解性和分散性,以提高治疗效果.
研究的目的:
- 开发基于酸盐的珠子,其中有多孔泽奥利特 (Z5A) 作为疏水生物活性化合物的载体,特别是黄素.
- 优化珠子制造参数以满足所需的物理特征,并评估它们在向药物输送方面的潜力.
主要方法:
- 含有Z5A二氧化的酸珠是使用挤出滴滴工艺制造的,并与化交叉连接.
- 工艺参数 (酸盐/CaCl2度,针尺,距离) 为珠子的球形和尺寸进行了优化.
- 福里埃变换红外光谱 (FTIR),差分扫描热量测量 (DSC) 和热重力测量分析 (TGA) 用于表征.
- 应用了酸盐 (CS) 涂层来修改稳定性和降解行为,在不同的pH值下进行了胀和降解研究.
主要成果:
- 优化的工艺参数产生了具有良好的球形性和1.5-1.7毫米的水合直径的酸盐/Z5A珠.
- FTIR,DSC和TGA证实了Z5A和黄素在酸盐基质中成功固定.
- 复合珠子由于酸盐矩阵而表现出pH响应性质.
- 酸盐涂层增强了珠子的稳定性和受控的降解,显示了酸盐填充剂的强化作用.
结论:
- 响应pH的酸盐/Z5A珠子是水性药物的有效载体,如黄素.
- 素修饰改善了珠子的稳定性和受控释放特性.
- 这些复合珠具有显著的潜力,可以将脂性药物向炎症部位.
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