使用盒式设计用于局部应用的提奥卡纳荷载的转基因凝:体外,体外和分子对接方法
Muhammad Imran Qureshi1, Qazi Adnan Jamil1, Faisal Usman2
1Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur 66000, Pakistan.
Gels (Basel, Switzerland)
|September 27, 2023
概括
提奥可纳 (TCZ) 装载的转基因组 (TE) 能够有效地克服皮肤屏障功能,从而增强抗真菌的作用. 这种新型凝配方显示出与市场品牌可比的显著疗效.
科学领域:
- 制药科学 制药科学
- 皮肤病学 皮肤病学
- 药物输送系统 药物输送系统
背景情况:
- 蒂奥可纳 (TCZ) 是一种广泛的抗真菌剂,由于其BCSII类属性,其透到皮肤是有限的.
- 开发有效的局部输送系统对于提高TCZ等透性较差药物的疗效至关重要.
- 晶体体体 (TEs) 提供了一个有前途的纳米载体方法,以改善通过角层的药物透.
研究的目的:
- 为提升局部输送制定和表征提奥卡纳 (TCZ) 载荷的转基因组 (TE).
- 评估 TCZ 载荷的 TEs 纳入凝配方的物理化学性质,皮肤透和抗真菌活性.
- 与商业产品相比,评估开发的TCZ载荷的转基因体凝的体内治疗疗效.
主要方法:
- 使用修改的冷方法和优化通过Box-Behnken设计制造TCZ装载的TE.
- 综合的物理化学表征,包括粒子大小,捕获效率 (EE) 和形态 (SEM).
- 评价凝特性 (pH,导电性,可传播性,质),药物含量,体外/体外透,体外/体内抗真菌活性. 分子对接被用来理解药物辅助剂相互作用.
主要成果:
- 优化TCZ载荷的TE表现出高的捕获效率 (高达86.13%) 和适合的粒子大小 (219.1757.1 nm) 与球形态.
- 凝配方显示出有利的物理化学特性和高药物透率 (高达92.03%),遵循希古奇的扩散模型.
- 观察到显著的体外和体外抗真菌活性,TCZ载荷的转基因体凝显示出与Canesten®相似的疗效.
结论:
- 装有TCZ的转菌体凝是一种有效的药物输送系统,用于局部抗真菌治疗.
- 开发的系统成功地克服了皮肤的角层屏障,提高了药物透和有效性.
- 增强的疏水性传递的TE有助于改善药物输送和治疗结果.
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