脂蛋白作为心血管疾病的危险因素:病理生理学和治疗前景
Pierandrea Vinci1, Filippo Giorgio Di Girolamo1,2, Emiliano Panizon1
1Clinica Medica, Cattinara Hospital, Department of Medical Surgical and Health Science, University of Trieste, 34149 Trieste, Italy.
International journal of environmental research and public health
|September 27, 2023
概括
高脂蛋白 (Lp) 水平是心血管疾病的独立风险因素,有助于残留风险. 本综述探讨了Lp(a) 病理生理学和有效的降低策略,包括新疗法.
科学领域:
- 心血管医学 心血管医学
- 遗传学 遗传学 是一个
- 药理学 药理学是指药理学的学科.
背景情况:
- 心血管疾病 (CVD) 仍然是导致死亡的主要原因,尽管预防和治疗方面取得了进展.
- 升高的脂蛋白[Lp[a]是心血管疾病的独立风险因素,即使控制了LDL-C,也会导致残留风险.
- Lp (a) 是一种类似于LDL的粒子,具有独特的阿波利波蛋白 (a) [Apo (a) ] 结构,在血度上表现出显著的个体间和种族间的变化.
研究的目的:
- 为当前对Lp (a) 病理生理机制的理解提供最新信息.
- 审查降低Lp (a) 水平的最有效策略.
- 突出新兴的替代疗法来管理高脂蛋白质血症 (a) 和残留心血管风险.
主要方法:
- 文献综述侧重于Lp (a) 病理生理学和降脂治疗.
- 对针对Lp的现有和新兴治疗策略的分析.
- 评估各种Lp减少方法的有效性和耐受性.
主要成果:
- 高Lp (a) 水平与缺血性心血管疾病,大动脉狭窄和心力衰竭的风险增加密切相关.
- 标准的降脂疗法在很大程度上对降低Lp (a) 无效.
- 新兴的疗法,如PCSK9抑制剂和反感性寡核酸,显示出有希望的结果,而非瑞斯是目前最有效的治疗方法.
结论:
- 高脂蛋白血症的有效管理对于控制残留心血管风险至关重要.
- 由于当前治疗方法的局限性,针对Lp (a) 的新疗法至关重要.
- 对Lp (a) 降低策略的进一步研究可以显著改善心血管疾病患者的结果.
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