结核菌菌菌菌感染驱动骨髓血液生成干细胞和原始细胞的差异反应
Suhas Bobba1, Nicole C Howard1, Shibali Das1
1Department of Molecular Microbiology, Washington University School of Medicine , St. Louis, Missouri, USA.
Infection and immunity
|September 27, 2023
概括
耐药性Mycobacterium结核菌感染会损害造血干细胞的反应. 与药物敏感菌株不同,耐药菌株无法诱导强大的免疫细胞生产,影响宿主防御机制.
科学领域:
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
- 微生物学 微生物学
背景情况:
- 造血干细胞和原始细胞 (HSPCs) 对于免疫对感染的反应至关重要.
- 结核菌菌 (Mtb) 感染可以通过I型干扰素 (IFN) 信号改变淋巴发育.
- 在Mtb中的耐药性 (DR) 突变可能会影响宿主-病原体相互作用和IFN产生.
研究的目的:
- 为了研究DR Mtb感染对血液形成区的体内影响.
- 探索DR Mtb如何影响HSPC反应和免疫细胞生产,与药物敏感的Mtb相比.
主要方法:
- 一个小鼠模型的Mtb感染 (药物敏感与DR).
- 在骨髓中分析造血细胞群.
- 血造干细胞 (HSC) 的单细胞RNA测序.
主要成果:
- 药物敏感的Mtb诱导了HSPC亚群扩张和淋巴发育.
- DR Mtb感染未能诱导HSPC扩张,导致骨髓中的颗粒细胞积累.
- 来自DR Mtb感染小鼠的HSC显示细胞因子信号通路的上调受损.
结论:
- DR Mtb 感染会使宿主的造血反应减弱,与药物敏感菌株不同.
- 这种受损的反应涉及HSCs无法激活关键信号通路的失败.
- 需要对这种病原体与宿主相互作用在血液形成水平上进行进一步的研究.
相关概念视频
Pulmonary Tuberculosis I
257
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
257
Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
Pulmonary Tuberculosis II
256
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
256
Bone Marrow Sampling and Transplants
352
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
352
Stem Cell Therapy for Tissue Regeneration
4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K
Pulmonary Tuberculosis III
357
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
357


