预防性炼和身体康复促进了多发性硬化症患者长期的潜在塑性表达
Mario Stampanoni Bassi1, Luana Gilio1,2, Fabio Buttari1
1IRCCS Neuromed, Pozzilli, Italy.
European journal of neurology
|September 27, 2023
概括
运动和康复可以改善多发性硬化症 (MS) 中的突触可塑性. 研究表明,运动在复发性复发性多发性硬化和渐进性多发性硬化患者中增强了长期潜能 (LTP) 表达,可能减少残疾.
科学领域:
- 神经科学是一个神经科学.
- 临床神经学 临床神经学
- 康复科学 康复科学 康复科学
背景情况:
- 长期潜能 (LTP) 表达的丧失与多发性硬化症 (MS) 疾病进展的恶化有关.
- 突触可塑性对认知和运动功能至关重要,其损伤是MS的标志.
- 运动和身体康复是增强突触可塑性的主要策略.
研究的目的:
- 调查体育炼对MS患者LTP类可塑性的影响.
- 为了确定预防性炼是否能改善早期复发性复发性多发性硬化 (RR-MS) 的突触可塑性.
- 评估神经康复对LTP类可塑性和进展性MS (PMS) 的临床结果的影响.
主要方法:
- 在46名RR-MS患者 (久坐或活跃) 中,使用间歇性甲基突破刺激评估了LTP类可塑性.
- 在接受8周康复计划的18名PMS患者中,评估了与配对关联刺激 (PAS) 的LTP类可塑性.
- 在MS患者和健康对照者之间比较突触可塑性表达.
主要成果:
- 与对照组相比,在RR-MS患者中观察到LTP表达的减少.
- 运动的RR-MS患者表现出比久坐患者更大的LTP表达.
- PMS患者的LTP降低,在康复后增加;基线LTP预测了手的灵巧度的改善.
结论:
- 预防性炼和身体康复可以增强MS中类似LTP的突触可塑性.
- 这些干预措施可能对减轻MS患者残疾累积产生有益影响.
- 通过运动准突触可塑性对MS治疗有希望.
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