抗菌多基基提德从海洋衍生的真菌Fusarium solani中分离出来 8388
Cankai Lin1, Rongchun Huang1, Juntao Liu1
1Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, and the NMPA Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, China.
Journal of fungi (Basel, Switzerland)
|September 27, 2023
概括
从海洋真菌Fusarium solani中分离了七种新型的多基菌,其中一些显示出对抗甲素耐药黄金葡萄球菌的抗菌活性,以及对癌细胞系的中度细胞毒性.
科学领域:
- 自然产品 化学 化学
- 海洋微生物学 海洋微生物学
- 药用化学 医学化学
背景情况:
- 海洋衍生真菌是一种丰富的新生物活性二次代谢产物来源.
- 众所周知,Fusarium物种可以产生各种生物活动的多种多样性.
研究的目的:
- 从海洋衍生的真菌Fusarium solani 8388.8.中分离和描述新的多基基菌.
- 评估分离化合物的抗菌和细胞毒性活动.
主要方法:
- 使用色谱技术分离和净化化合物.
- 通过全面的光谱数据分析 (NMR,MS) 阐明结构.
- 对抗菌活性 (MIC确定) 和细胞毒性 (CC50确定) 的生物测试.
主要成果:
- 发现了七种新型的多基化物 (富沙里索林F-K和富沙林I),以及三种已知的化合物.
- 富沙里索林F表现出二二基和乙烯氧化物单元的罕见组合.
- 富沙里索林I,富沙里索林J和5-deoxybostrycoidin显示出针对耐美西林黄金葡萄球菌的显著抗菌活性.
- 富沙里索林J对HeLa,A549和KB癌细胞系表现出中度细胞毒性.
结论:
- 海洋衍生的真菌Fusarium solani 8388产生了各种各样的新型多叶虫.
- 其中一些化合物具有有前途的抗菌和细胞毒性,需要进一步研究药物开发.
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