停止使用阿佐尔治疗原发性肺性菌菌症后的血清复苏:一个病例控制的观察性研究
Priyal J Shah1, Neil M Ampel1, Marlene E Girardo2
1Division of Infectious Diseases, Mayo Clinic, Phoenix, AZ 85054, USA.
Journal of fungi (Basel, Switzerland)
|September 27, 2023
概括
血清学反弹,在菌菌治疗后补体固定 (CF) 位数的增加,并不常见,但导致随访时间更长. 持续监测对于早期发现症状和潜在传播至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 菌类学 菌类学是指菌类学.
- 临床医学 临床医学
背景情况:
- 原发性肺性菌菌症需要抗真菌治疗.
- 停止治疗可能导致血清学反弹,定义为补体固定 (CF) 位数>2稀释升高.
- 患有血清性反弹的患者的结果需要进行表征.
研究的目的:
- 鉴定了患者的临床结果,主要的肺菌菌,经历了抗真菌治疗后的血清学反弹.
- 为了比较患者的结果 血清学反弹与匹配的对照没有反弹.
主要方法:
- 对于患有原发性肺性皮小菌病的患者进行了回顾性图表审查.
- 纳入标准:免疫能力强,未怀孕的成年人接受抗真菌药物治疗,随后有血清学反弹.
- 匹配的对照组没有血清学反弹.
主要成果:
- 58名患者经历了血清学反弹,52%与症状相关,9%与放射性进展相关.
- 恢复的中位时间为3.5个月; 63.7%需要重新开始抗真菌治疗.
- 复发的患者有更多的治疗后症状和更长的随访时间,但胸外传播没有增加.
结论:
- 在初级肺性菌瘤治疗后的血清复发不常见,但与长时间的临床随访有关.
- 持续监测患者对于检测后续症状和胸外传播至关重要.
- 了解血清反弹有助于在治疗后管理菌菌病患者.
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