儿童和青少年的BoDV-1感染:系统性审查和元分析
Matteo Riccò1, Ilaria Zanella2, Elia Satta2
1Occupational Health and Safety Service on the Workplace/Servizio di Prevenzione e Sicurezza Ambienti di Lavoro (SPSAL), Department of Public Health, AUSL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy.
波尔纳疾病病毒1 (BoDV-1) 在儿童和青少年中循环,抗体血清流行率为6.09%. 这表明年轻人群中可能存在未知的传播途径.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 儿科 儿科 儿科
背景情况:
- 波尔纳疾病病毒1 (BoDV-1) 在人类中引起严重的脑髓炎.
- 波德维-1的流行病学,特别是在儿科人群中,需要进一步澄清.
研究的目的:
- 系统地审查和总结BoDV-1在儿童和青少年 (<18岁) 的血清流行率.
- 评估BoDV-1在这个人口群体中的传播情况.
主要方法:
- 在PubMed,EMBASE和MedRxiv数据库中进行系统的文献搜索.
- 包括报告BoDV-1抗原和抗体血清流行率在18岁以下的人群中的研究.
- 从六项涉及2692名受试者的已确定研究中对数据进行了聚合分析.
主要成果:
- 计算了BoDV-1抗体的6.09% (95% CI 2.1416.17) 的汇总血清流行率.
- 确定了BoDV-1抗原的0.76% (95% CI 0.262.19) 的综合血清流行率.
- 在流行率估计中观察到显著的异质性.
结论:
- 血清发病率数据表明,BoDV-1在儿童和青少年中存在大量的循环.
- 有限的暴露机会表明,未知载体可能参与到BoDV-1向年轻人传播的过程中.
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