牛皮患者接受生物治疗的癌症风险:一项全国性基于人口的研究
Joon Min Jung1, Ye-Jee Kim2, Sung Eun Chang1
1Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
Journal of cancer research and clinical oncology
|September 27, 2023
概括
牛皮患者面临更高的癌症风险. 瘤坏死因子-α (TNF-α) 抑制剂会增加整体癌症和淋巴瘤的风险,而干白素 (IL) -12/23抑制剂不会增加癌症的风险.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 牛皮是一种慢性炎症性疾病.
- 针对瘤亡因子-α (TNF-α) 和白内素 (ILs) 的生物疗法用于中度至重度的牛皮.
- 这些疗法与癌症风险之间的关联需要进一步研究.
研究的目的:
- 评估牛皮患者的整体和特定癌症风险.
- 确定TNF-α抑制剂和IL-12/23抑制剂治疗对这些患者癌症风险的影响.
主要方法:
- 一项基于人口的队列研究,使用韩国医疗保险审查和评估服务数据库 (2008-2019).
- 在牛皮患者中计算整体和特定癌症的标准化发病率 (SIR).
- 采用多变量考克斯回归模型来评估TNF-α抑制剂和IL-12/23抑制剂暴露对癌症风险的影响.
主要成果:
- 牛皮患者的整体癌症风险显著增加 (SIR,1.12).
- 使用TNF-α抑制剂与整体癌症风险增加有关 (aHR, 1.41) 和非霍奇金淋巴瘤 (aHR, 2.98).
- 使用IL-12/23抑制剂与显著降低整体癌症风险相关 (aHR,0.57).
结论:
- 牛皮患者的TNF-α抑制剂治疗与整体癌症和淋巴瘤的风险增加有关.
- 治疗IL-12/23抑制剂与任何癌症的风险增加无关.
- 固体器官癌症的风险没有受到TNF-α抑制剂治疗的显著影响.
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