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严重精神疾病中抗精神病诱导的体重增加:危险因素和特别考虑
Nicolette Stogios1,2, Bailey Humber1,2, Sri Mahavir Agarwal1,2,3,4
1Schizophrenia Division, Centre for Addiction and Mental Health (CAMH), 1051 Queen Street West, Toronto, ON, M6J 1H3, Canada.
Current psychiatry reports
|September 27, 2023
概括
抗精神病药物诱导的体重增加 (AIWG) 是一个常见的副作用. 甲胺在治疗AIWG方面表现有前途,但为了有效预防和治疗,需要更多的研究和临床指导.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 内分泌学 在内分泌学.
背景情况:
- 体重增加是抗精神病 (AP) 药物的显著不良影响.
- 抗精神病药物诱导的体重增加 (AIWG) 影响患者的坚持和治疗结果.
- 了解AIWG的流行,原因和风险因素对于临床管理至关重要.
研究的目的:
- 审查有关AIWG流行,病因和风险因素的当前知识.
- 总结有关AIWG管理干预措施的证据.
- 讨论AIWG的特殊考虑和未来研究方向.
主要方法:
- 对抗精神病药物诱导的体重增加研究的文献综述.
- 综合有关风险因素的数据,包括患者和治疗相关的变量.
- 对药理学和生活方式干预措施的证据评估.
主要成果:
- 对AIWG的诱导因素包括先前的抗精神病药物暴露,性别和年龄.
- 与治疗相关的因素,如抗精神病剂量和持续时间,也会导致AIWG.
- 梅特福林在AIWG目前的干预措施中显示出最强有力的证据.
结论:
- 在临床指南中,越来越多地推甲胺用于AIWG管理.
- 建议采取生活方式干预措施,但在成本效益和可扩展性方面存在局限性.
- 进一步的研究和加强的临床培训对于AIWG预防和管理是必要的.
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