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脑髓状细胞子组的单细胞映射揭示了在缺血性中风后有利于神经可塑性的关键转录组变化

Fangxi Liu1, Xi Cheng2, Chuansheng Zhao1,3

  • 1Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.

Neuroscience bulletin
|September 27, 2023
PubMed
概括

单细胞测序揭示了脑免疫细胞,包括微质细胞和单细胞衍生的巨细胞,如何相互作用,促进中风后的神经修复. 这种交叉声调节抗炎反应,并通过特定的信号通路增强神经发生.

关键词:
缺血性中风是因为缺血性中风.微质细胞中的微质细胞单细胞衍生的巨细胞.神经新生是什么意思 神经新生是什么意思单细胞测序是一种单细胞测序.

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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...