尿酸皮体分析识别了早期和高级CKD的常见和特定阶段标记物
Sam Hobson1, Emmanouil Mavrogeorgis2,3, Tianlin He2
1Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 141 52 Stockholm, Sweden.
Proteomes
|September 27, 2023
概括
慢性病 (CKD) 中尿分析确定了关键的原片段. 早期的CKD进展标志物可能使个性化干预成为可能,与后期不同.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物化学 生物化学
- 蛋白质组学是指蛋白质组学.
背景情况:
- 慢性病 (CKD) 的进展是一个连续的过程,在不同阶段具有不同的分子驱动因素.
- 非侵入性生物标志物对于指导治疗决定在CKD管理中至关重要.
- 尿组分析提供了一种有效的方法,用于发现病中的生物标志物.
研究的目的:
- 为了确定与不同疾病阶段的CKD进展相关的尿.
- 区分早期和晚期CKD之间的分子决定因素.
- 在不同疾病阶段区分慢慢和快速进展的CKD.
主要方法:
- 分析了317名早期 (2期) 和晚期 (3b-5期) 的CKD患者的尿液样本.
- 毛细管电泳与质谱学 (CE-MS) 结合,用于皮层的概况.
- 在早期和晚期CKD之间进行了统计比较,以及缓慢与快速进展者.
主要成果:
- 在早期和晚期CKD之间发现了总共929种显著不同的,其中许多是下调的,其中268种来自原.
- 在早期CKD中,在缓慢和快速进展者之间确定了42种改变的,其中30种是原片段,这表明早期的结构变化可能是可逆的.
- 只有四个片在晚期CKD的缓慢和快速进展之间存在差异,这表明晚期疾病中存在明显的致病过程.
结论:
- 尿原蛋白片在早期CKD进展中发生显著变化.
- 这些早期进展标志物可能为个性化CKD患者管理提供一种非侵入性方法.
- 在CKD进展中的致病机制在早期和晚期疾病阶段之间存在显著差异.
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