微塑料对实验性急性结肠炎形态表现的影响
Natalia Zolotova1, Dzhuliia Dzhalilova1, Ivan Tsvetkov1
1Department of Immunomorphology of Inflammation, Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", 117418 Moscow, Russia.
Toxics
|September 27, 2023
概括
微塑料的消费,特别是聚乙烯颗粒,在小鼠中恶化了结肠炎. 这项研究揭示了微塑料改变了结肠形态,并加剧了炎症性肠病症状.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 胃肠病学 胃肠病学
背景情况:
- 微塑料污染是一个日益严重的环境问题,可能会对人类健康产生影响.
- 新出现的证据表明,微塑料暴露与炎症性肠病 (IBD) 的发病率上升之间可能存在联系.
研究的目的:
- 为了研究慢性聚乙烯微粒消费对健康小鼠结肠的形态影响.
- 为了确定微塑料的摄入如何影响小鼠中硫酸 (DSS) 诱导的急性结肠炎的严重程度.
主要方法:
- 雄性C57BL/6小鼠在6周内服用了2.3毫克/公斤/天的聚乙烯微粒 (直径为5微米).
- 在小鼠的一个子组中,使用1%的硫酸 (DSS) 溶液诱导急性结肠炎.
- 分析了结肠组织的形态变化,包括细胞计数,粘素含量和免疫细胞分布.
主要成果:
- 在健康的小鼠中,微塑料暴露导致内分泌细胞增加,硫化粘膜增加,自身膜细胞增加,巨细胞数量减少.
- 微塑料消费显著恶化了DSS诱导的大肠炎,其特征是和炎症增加.
- 在暴露于微塑料和DSS的小鼠中观察到杯细胞内的中性粘膜的减少.
结论:
- 聚乙烯微粒在小鼠结肠中诱导显著的形态变化.
- 摄入微塑料会加剧急性结肠炎的严重程度,这表明在炎症性肠病的发病过程中可能发挥作用.
- 需要进一步的研究来阐明微塑料诱导的肠道炎症背后的机制及其对人类健康的临床相关性.
相关概念视频
01:21Plastic Behavior
A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and reloaded.
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:19Appendicitis
Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...