在大鼠中,在亚慢性腹腔内暴露于元素氧化物纳米颗粒后,有毒损伤
Yuliya V Ryabova1, Ilzira A Minigalieva1, Marina P Sutunkova1
1Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Yekaterinburg, Russia.
Toxics
|September 27, 2023
概括
元素氧化物纳米颗粒 (NP) 在老鼠中引起损伤,影响管和细胞结构. 毒性严重程度因NP类型而异,使病的早期诊断复杂化.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 材料科学 材料科学 材料科学
背景情况:
- 慢性泌尿器官疾病,包括脏病,可能源于工作场所的化学物质暴露.
- 来自工业副产品的纳米颗粒对脏和丸等器官构成潜在风险.
研究的目的:
- 在老鼠模型中研究各种元素氧化物纳米粒子 (NP) 的毒性.
- 评估亚慢性暴露于特定NP对功能和结构的影响.
主要方法:
- 鼠接受了合成Al2O3,TiO2,SiO2,PbO,CdO,CuO和SeONP的重复腹腔内注射.
- 暴露后分析了脏重量,血液和尿液的生物化学参数,脏组织学和脏细胞形态学.
主要成果:
- 所有测试的元素氧化物NP在次慢性暴露后都表现出毒作用.
- 组织形态变化包括表皮脱皮和刷边缘损失,近端管的损伤更大.
- 生物化学变化各不相同,一些NP降低了血清肌/尿素,而另一些则增加了尿路标记物,表明了复杂的影响.
结论:
- NPs的化学性质显著影响损伤的严重程度.
- 观察到的组织形态变化并不总是与生化标志物相关,这阻碍了对损伤的早期临床诊断.
- 需要进一步的研究来确定早期毒性检测的关键指标.
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