暴露于颗粒物中的[a]皮烯和1-皮烯会增加人体中氧化应激
Sun-Haeng Choi1,2, Bolormaa Ochirpurev3, Akira Toriba4
1Department of Occupational and Environmental Medicine, Chungbuk National University Hospital, Cheongju 28644, Republic of Korea.
暴露于空气中的[a]烯 (BaP) 会增加氧化应激,由更高的8-氧化氨酸 (8-OHdG) 水平表明. 虽然1 - 尼托烯 (1-NP) 没有直接联系,但其代谢物1 - NAAP与8-OHdG的增加有关.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 生物化学 生物化学
背景情况:
- 多环芳 (PAH) 是与氧化应激相关的环境污染物.
- [a]二烯 (BaP) 和1-二烯 (1-NP) 是令人担忧的关键大气PAH.
- 氧化应激在各种代谢和疾病过程中发挥着作用.
研究的目的:
- 在韩国成年人中调查大气中暴露于BaP和1-NP和氧化应激生物标志物之间的关联.
- 评估PAH特定代谢物和氧化应激标志物之间的关系.
- 为了确定PAH暴露的季节性变化及其对氧化应激的影响.
主要方法:
- 研究人口:44名韩国成年人在州.
- 测量:大气中的BaP和1-NP,尿中的6-OHNP,1-NAAP,1-OHP,TBARS和8-OHdG.
- 统计分析以将暴露和生物标志物水平关联起来,考虑到季节性.
主要成果:
- 在冬季和夏季,尿液中的TBARS和6-OHNP水平显著不同.
- 大气中的BaP暴露与夏季尿路8-OHdG增加显著相关.
- 尿中的1-NAAP度是夏季尿中的8-OHdG的显著预测因素;1-NP没有直接相关性.
结论:
- 吸入暴露于BaP有助于增加氧化应激,由更高的8-OHdG证明.
- 1-NP的代谢物,特别是1-NAAP,与高氧化应激标志物8-OHdG有关.
- 季节性因素影响PAH代谢物水平及其与氧化应激标志物的关联.
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