在短期激素戒断期间,口服避孕药使用者的心理健康症状
Isabel A Noachtar1, Vibe G Frokjaer2,3,4, Belinda Pletzer1
1Department of Psychology and Centre for Cognitive Neuroscience, University of Salzburg, Salzburg, Austria.
JAMA network open
|September 27, 2023
概括
在避孕药暂停期间取消荷尔蒙避孕药与增加负面影响和焦虑有关,类似于自然的月经周期波动. 持续使用口服联合避孕药 (COC) 可能有助于情绪稳定.
科学领域:
- 生殖健康 生殖健康
- 心理健康 心理健康
- 内分泌学 在内分泌学.
背景情况:
- 荷尔蒙避孕药与情绪变化有关,但长期影响,特别是在戒断阶段,研究不足.
- 对于使用者来说,了解联合口服避孕药 (COCs) 月度避孕药暂停对心理健康的影响至关重要.
研究的目的:
- 调查COC药片暂停期间的短期荷尔蒙戒断是否与长期使用者的情绪变化和情绪识别有关.
- 为了比较COC药片暂停期间的情绪波动与自然月经周期月经阶段的情绪波动.
主要方法:
- 一项涉及181名女性 (18-35岁) 的病例控制研究,使用COC至少6个月,并与自然月经周期的对照组进行了对照研究.
- 参与者每月进行两次评估:一次在活性药片阶段/乳液阶段,一次在药片暂停/月经期间.
- 评估负面影响,焦虑和心理健康症状;在戒断阶段计算的百分比变化.
主要成果:
- 与活性药片阶段相比,COC使用者在药片暂停期间经历了负面影响 (12.67%),焦虑 (7.42%) 和心理健康症状 (23.61%) 的显著增加.
- 避孕药暂停期间的情绪变化与在自然月经周期中观察到的情绪波动相似.
- 药片暂停期间情绪恶化的增加在COC使用者中更为明显,基线抑郁症得分较高.
结论:
- 在COC药片暂停期间的荷尔蒙戒断与不良的心理健康症状有关,类似于月经期间的内源性类固醇戒断.
- 从心理健康的角度来看,这些发现质疑了药丸的常规使用.
- 持续的COC摄入可能为长期使用者提供情绪稳定益处.
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