农村和非农村环境中的技术辅助布普伦诺芬治疗:两项随机临床试验
Stacey C Sigmon1,2,3, Kelly R Peck1,2,3, Sydney R Batchelder1,2
1Vermont Center on Behavior and Health, University of Vermont, Burlington.
JAMA network open
|September 27, 2023
概括
技术辅助布普伦诺芬 (TAB) 治疗在24周内显著改善了农村和非农村成年人的阿片类药物戒断. 这种方法,包括过量教育,在服务不足的地区显示出对阿片类药物使用障碍的有效性.
科学领域:
- 成 药物 药物 药物 药物
- 数字健康数字健康
- 公共卫生 公共卫生
背景情况:
- 扩大阿片类药物使用障碍 (OUD) 治疗范围至关重要,特别是在面临进入障碍的农村社区.
- 技术辅助布伦诺芬 (TAB) 为扩大治疗范围提供了一个潜在的解决方案.
- 之前关于TAB疗效的研究没有评估更长的持续时间或包括过量教育.
研究的目的:
- 评估TAB在24周内对OUD患者的疗效.
- 评估TAB协议中添加过量教育的影响.
- 为了确定TAB有效性,特别是在居住在农村社区的个人中.
主要方法:
- 两个平行24周的随机临床试验涉及未经治疗的OUD的成年人.
- 参与者被随机分配到TAB或对照组.
- TAB组每两个月服用药物,每晚接收交互式语音响应 (IVR) 电话,随机回电,并通过iPad提供关于艾滋病毒,C型肝炎病毒 (HCV) 和过量预防的教育.
主要成果:
- 与农村和非农村试验中的对照组相比,TAB组的非法阿片类药物戒断率显著更高 (85.3%和88.0%对比24.0%和21.3%).
- 治疗坚持度很高,约99%的布普伦诺芬,超过92%的IVR系统参与.
- 通过iPad提供的教育导致了关于艾滋病毒,HCV和过量服用的知识的显著和持续增长.
结论:
- 技术辅助布普伦诺芬 (TAB) 治疗对于在24周内实现阿片类药物戒断是有效的.
- TAB的有效性扩展到农村社区的患者,解决治疗机会差异.
- 将过量药物教育纳入TAB协议中,可以增强知识并支持治疗目标.
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