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对SARS-CoV-2主要蛋白酶抑制剂的结构-活性关系研究,含有4-Fluorobenzothiazole-2-carbonyl组的研究

Kohei Tsuji1, Takahiro Ishii1, Takuya Kobayakawa1

  • 1Department of Medicinal Chemistry, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), Chiyoda-ku, Tokyo 101-0062, Japan.

Journal of medicinal chemistry
|September 27, 2023
PubMed
概括

新的候选药物TKB245和TKB248对SARS-CoV-2主要蛋白酶 (Mpro) 具有高强度,可以抑制病毒复制. TKB248为潜在的COVID-19治疗提供了改进的药理动力学特性.

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