相关实验视频

Updated: Jul 15, 2025

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

自体内皮原体细胞和生物活性因子改善膀再生

Bin Yang¹, Guanjie Yang¹, Feng Zhao²

¹Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Tissue engineering. Part C, Methods

|September 27, 2023

概括

结合生物材料,细胞和生长因子显著改善了膀组织工程. 这种方法增强了光滑肌肉的再生和血管化,从而使组织工程膀的功能恢复更好.

科学领域:

再生医学是一种再生医学.
生物材料科学生物材料科学
血管生物学血管生物学

背景情况:

不够的血管化阻碍了膀组织工程和光滑肌肉再生.
开发用于组织工程膀的有效策略需要解决复杂的再生过程.

研究的目的:

调查是否结合生物材料,细胞和生物活性因素可以改善组织工程膀的光滑肌肉再生和血管化.
为了评估多途径方法对膀增大的疗效.

主要方法:

猪膀非细胞基质 (BAM) 被自主膀光滑肌细胞 (BSMC) 和内皮原生细胞 (EPC) 播种.
外源性血管内皮生长因子 (VEGF) 和血小板衍生生长因子BB (PDGF-BB) 与Matrigel一起使用.
细胞-BAM复合体在子模型中植入用于膀增大.

主要成果:

实验组与对照组相比,显著改善了光滑肌肉再生和血管化.
在实验组中观察到组织工程膀功能恢复的增强.
细胞追踪证实了种子EPCs在新血管化的直接参与.

结论:

结合自身EPCs,BSMCs,BAM和生物活性因子 (VEGF,PDGF-BB) 是组织工程尿膀的有效策略.
这种多途径的方法成功地解决了膀再生中的血管化挑战.
这些发现表明,这是一种有希望的方法,可以改善膀组织工程的结果.

关键词:

膀无细胞矩阵的膀.膀再生膀再生内皮前代细胞的前代细胞.增长因素增长因素增长因素组织工程是组织工程.

更多相关视频

Decellularization and Recellularization Methodology for Human Saphenous Veins

Decellularization and Recellularization Methodology for Human Saphenous Veins

Published on: July 27, 2018

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

相关概念视频

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...

Whole Body Regeneration

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...