通过一种生物灵感的口腔伸展贴来促进的全身吸收
Zhi Luo1,2, David Klein Cerrejon2, Simon Römer2
1Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, P.R. China.
Science translational medicine
|September 27, 2023
概括
一个新的吸附贴片通过拉伸口腔粘膜和使用透增强剂来增强口服药物吸收. 这项技术显著改善了狗的类药物生物可用性,并在人体试验中显示出有前途.
科学领域:
- 生物技术是生物技术.
- 药物输送系统 药物输送系统
- 生物制药产品 生物制药产品
背景情况:
- 蛋白质和类生物制药是有效的,但由于口服吸收不佳,需要通过肠道给药.
- 现有的口服配方与增强剂的成功程度有限.
- 目前用于胃肠道药物输送的侵入性方法缺乏经过证明的安全性和稳定性.
研究的目的:
- 为增强口服药物吸收开发一种创新技术.
- 为了克服对宏分子药物的上皮屏障.
- 创建一个安全有效的平台,用于口服交付.
主要方法:
- 设计了一个自适应的吸贴,灵感来自于章鱼吸器.
- 结合口腔粘膜与透增强剂的非侵入性拉伸.
- 在狗模型和第一次在人体研究中测试了这项技术.
主要成果:
- 与商业药片相比,desmopressin在狗中实现了高达两倍的生物可用性.
- 在没有进一步优化的情况下,证明的全身暴露与口服赛马格卢类药物相当.
- 在40名健康参与者中确认了剂型的可接受性和耐受性.
结论:
- 吸附贴片技术有效地提高了口服药物的吸收.
- 这个平台提供了一个简单的,非侵入性的,并可能可翻译的方法,用于口服递送.
- 该技术对改善患者的服药性和对宏分子药物的治疗结果显示出希望.
相关概念视频
01:18Drug Delivery: Enteral Route
489
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
489
01:22Drug Delivery: Miscellaneous Routes
371
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
371