半孔矩阵作为多重多态活性药物成分阿里皮普拉的有希望的新一代载体
Aldona Minecka1, Magdalena Tarnacka2, Karolina Jurkiewicz2
1Department of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland.
纳米技术通过将阿里皮普拉 (APZ) 等活性药物成分 (API) 封装到多孔膜中来增强药物输送. 这可以防止结晶,并提供延长释放效果,改善生物可用性.
科学领域:
- 制药科学 制药科学
- 纳米技术 纳米技术
- 材料科学 材料科学 材料科学
背景情况:
- 在现代药物开发中,提高活性药物成分 (API) 的溶解性和生物可用性至关重要.
- 纳米技术提供了创新的策略,特别是使用多孔纳米结构材料来改善API属性.
- 抗精神病药物阿里皮普拉 (APZ) 面临着难以溶解和低生物可用性的挑战.
研究的目的:
- 与其散装形式相比,研究将APZ纳入中等孔矩阵的优势.
- 分析纳米限制对APZ结晶动力学,分子动力学和物理稳定性的影响.
- 评估APZ在中孔载体中的溶解概况和沉行为.
主要方法:
- APZ透到中孔矩阵中:阳极氧化,原生和化 (孔径为8-10 nm).
- 热度测量调查和取决于温度的X射线衍射以研究结晶.
- 介电光谱法用于评估分子动力学和稳定性.
- 溶解研究以确定药物释放特征.
主要成果:
- 与散装APZ (III,IV,I) 相比,受限APZ在加热时表现出不同的多态形式 (I和III).
- 在一个月的储存时间内,在298K的温度下,没有观察到受限APZ的结晶.
- 所有的封闭系统都显示出随着时间的推移,溶解的逻辑增长,模仿长时间释放而没有降水.
结论:
- 半孔矩阵是不稳定的无形API如APZ的有效载体,防止结晶.
- 纳米结构载体提供延长释放效果,可能增加生物可用性.
- 这种"纳米结构化"方法为改善治疗结果提供了一代新型药物载体.
更多相关视频
10:27Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides
Published on: July 14, 2015
11:13Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules
Published on: August 19, 2015
相关概念视频
Pore Transport and Ion-Pair Transport
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
Drug Absorption Mechanism: Carrier-Mediated Membrane Transport
Facilitated diffusion is a passive process that utilizes human Solute Carrier (SLC) transporters. These transporters bind to the drug, undergo structural...
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Carrier-Mediated Transport
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
Drug Absorption Mechanism: Passive Membrane Transport
