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以体静止素受体为导向的PET/CT可以区分不同类型的头部和部偏结质瘤

Yingjun Zhi¹, Elena Gerhard-Hartmann², Philipp E Hartrampf³

¹From the Department of Otorhinolaryngology, Plastic, Aesthetic, and Reconstructive Head and Neck Surgery, University Hospital Würzburg.

Clinical nuclear medicine

|September 27, 2023

概括

以体静止素受体 (SSTR) 导向的PET/CT成像可以识别头部和部偏瘤 (HNPGLs) 和转移. 定量PET指标,特别是目标与背景比率 (TBR),区分HNPGL亚型.

科学领域:

神经内分泌瘤的神经内分泌瘤
医学成像医学成像
在瘤学瘤学.

背景情况:

头部和部副瘤 (HNPGLs) 起源于神经内分泌细胞.
索马托斯坦素受体 (SSTR) 导向的PET/CT是HNPGLs的潜在成像模式.

研究的目的:

评估体内PET信号是否能够区分不同的HNPGL亚型.
评估SSTR-PET/CT在HNPGL成像中的实用性.

主要方法:

14名HNPGL患者使用68Ga-DOTATOC进行了SSTR-PET/CT.
患者被分为下副瘤 (PGL-J),大脑动脉副瘤 (PGL-C) 和带SDHx变异的PGL-C (PGL-C-SDH).
进行了对原发性瘤的视觉和定量评估 (SUVmax,TBR),并在子组之间进行了比较.

主要成果:

所有的初级HNPGL都在SSTR-PET/CT上可识别.
PGL-J显示SUVmax显著高于PGL-C-SDH.
TBR显著区分了PGL-J与PGL-C和PGL-C-SDH之间的差异.
在2/3的PGL-C-SDH患者中检测到转移.

结论:

SSTR-PET/CT有效地识别了原发性和转移性HNPGL疾病.
升高的TBR表明HNPGLs的图像对比度很好.
基于PET的量化可以区分不同的HNPGL亚型.

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