68 Ga-PSMA-Avid 结肠癌的肝转移,没有在FDG PET扫描上可视化
Abtin Doroudinia1, Satyanarayana Chekuri
1From the Department of Radiology, UT Southwestern Medical Center, Dallas, TX.
Clinical nuclear medicine
|September 27, 2023
概括
这项案例研究突出显示,-68前列腺特异性膜抗原 (68Ga-PSMA) 在患有结肠癌的患者中激发肝转移. 这些病变最初在18F-FDG PET/CT上呈阳性,在治疗后显示FDG狂热率降低,通过活检确认结肠来源.
科学领域:
- 核医学就是核医学.
- 在瘤学瘤学.
- 放射性药物 放射性药物 放射性药物
背景情况:
- 18F-FDG PET/CT是评估结肠癌转移和治疗反应的标准.
- 前列腺特异性膜抗原 (PSMA) PET成像主要用于前列腺癌的检测.
研究的目的:
- 在患有结肠癌的患者中报告一个68Ga-PSMA激发性肝转移的独特病例.
- 在FDG PET/CT扫描上调查肝转移的变化程度.
- 探索PSMA作为超前列腺癌之外的治疗药物的潜力.
主要方法:
- 一个74岁的男性患有结肠癌和前列腺癌的案例介绍.
- 使用18F-FDG PET/CT用于初始分期和治疗后反应评估.
- 使用68Ga-PSMA PET/CT来评估肝脏病变.
- 进行了PSMA-avid肝病变的活检,以获得他的病理学确认.
主要成果:
- 确诊了肝转移,并最初对18F-FDG PET/CT.
- 随后的治疗后的18F-FDG PET/CT扫描显示,这些病变中的FDG狂热度下降.
- 活检证实了PSMA-avid肝病变是结肠起源的转移.
- 在这些非前列腺癌转移的新血管中证实了PSMA的表达.
结论:
- PSMA可以在结肠癌肝脏转移的新血管中表达.
- 这一案例证明了68Ga-PSMA PET/CT在评估结肠癌转移中的潜力.
- 基于PSMA的成像和治疗 (疗法) 可能在瘤学中具有更广泛的应用.
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