睡眠和昼夜活动对血液中酒精度的影响
Mary Beth Miller1, Roberto U Cofresí2, Denis M McCarthy2
1Department of Psychiatry, University of Missouri School of Medicine, Columbia, MO, USA.
Sleep
|September 27, 2023
概括
睡眠和昼夜节律显著影响酒精的药理动力学. 早上喝酒,当昼夜警报低时,可能导致血液中酒精度 (BAC) 更高.
科学领域:
- 睡眠科学 睡眠科学
- 时间生物学 时间生物学
- 酒精的药理学 酒精的药理学
背景情况:
- 成年人的主观中毒水平与疲劳和睡眠剥夺有关.
- 在临床实践中,睡眠通常不被认为是血液中酒精度 (BAC) 的预测指标.
- 了解睡眠和昼夜时间对酒精影响的影响对于临床工作和研究至关重要.
研究的目的:
- 审查有关睡眠 (过程S) 和昼夜 (过程C) 因素对BAC指标的影响现有数据.
- 为临床实践提供信息,并指导酒精药理学未来的研究方向.
- 综合人类和动物模型关于睡眠,昼夜节律和酒精影响的发现.
主要方法:
- 在医学和心理数据库中进行文献搜索.
- 识别了操纵睡眠/循环节因素的物品,并报告了对酒精药理学的影响 (例如,BAC,新陈代谢).
- 审查了21篇符合入选标准的全文文章,从最初的86.
主要成果:
- 对日间时间对酒精药理学影响的证据最令人信服.
- 循环阶段 (过程C) 显示了一些影响,但卧床时间 (过程S) 没有.
- 峰值BAC通常发生在生物一天的早期,在这个时候,酒精的排泄可能更慢.
结论:
- 环节因素可能会影响酒精的药理动力学,可能是通过改变酒精的排泄率.
- 由于较低的昼夜警报,个人在早上饮酒时可能会经历更高的BAC.
- 酒精预防和干预策略应纳入睡眠和昼夜健康,因为这些因素有助于酒精相关的伤害.
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