与社交饮酒者相比,患有AUD的患者在睡眠期间表现出心率变化减弱的情况
Stephanie E Wemm1, Max Golden2, Jorge Martins1,3
1Department of Psychiatry, Yale Stress Center, Yale School of Medicine, 2 Church St South Suite 209, New Haven, CT 06519, United States.
Alcohol and alcoholism (Oxford, Oxfordshire)
|September 27, 2023
概括
长期大量饮酒会损害自主神经系统的功能,特别是睡眠期间的副交感活动. 心率变化 (HRV) 测量显示了酒精使用障碍 (AUD) 和社交饮酒者之间的显著差异,与临床症状相关.
科学领域:
- 心血管生理学心血管生理学
- 自主神经系统研究 自主神经系统研究
- 酒精使用障碍研究研究 酒精使用障碍
背景情况:
- 慢性重度饮酒与严重的心血管疾病有关.
- 心率变化 (HRV) 反映了自主神经系统 (ANS) 功能及其适应生物和环境需求.
- 以前的研究表明,酒精会影响心血管健康,但实际上,对AUD患者的HRV持续监测的研究较少.
研究的目的:
- 与社交饮酒者相比,研究中度至重度酒精使用障碍 (AUD) 患者在清醒和睡眠状态期间HRV指标的变化.
- 评估持续的,现实世界的HRV测量和患者报告的AUD患者症状之间的关系.
- 为了确定被动生物监测是否可以在日常生活中检测AUD中的自主功能障碍.
主要方法:
- 一项涉及寻求治疗的中度至重度AUD (n=16) 和社交饮酒者 (n=10) 的比较观察性研究.
- 通过被动生物监测对每位参与者进行持续的现实心率监测,平均每人5.27天.
- 分析了五个关键的HRV指数 (呼吸道鼻失常幅度,高频,低频,高频/低频比,RMSSD,SDNN) 在清醒和睡眠时间.
主要成果:
- 随着更长的清醒时间,RMSSD和SDNN都显著下降,这表明在长时间清醒期间HRV降低.
- 在睡眠期间,与社交饮酒者相比,AUD患者的HF,RSA振幅,RMSSD和SDNN显著降低,这表明副交感活动受损.
- 睡眠和清醒期间的HRV测量与AUD组中患者报告的抑郁和睡眠困难有显著的相关性.
结论:
- 在现实环境中持续的自主生物监测有效地检测了AUD患者在睡眠期间的副交感功能障碍.
- HRV指标,特别是在睡眠期间,是与AUD相关的自主失调的敏感指标.
- 观察到的AUDHRV变化具有临床相关性,与患者报告的症状相关,突出了客观评估和监测的潜力.
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