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Updated: Jul 15, 2025

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
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Published on: January 27, 2023

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Jagged1作为RBP-J目标和反作用抑制TNF介导的炎症性骨质结晶发生

Courtney Ng1, Yongli Qin1,2, Yuhan Xia1

  • 1Arthritis and Tissue Degeneration Program, David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY.

Journal of immunology (Baltimore, Md. : 1950)
|September 27, 2023
PubMed
概括

瘤亡因子 (TNF) 在炎症性疾病中驱动骨质损失. 我们发现Jagged1,一个Notch连接体,抑制了TNF诱导的骨质细胞形成,为炎症性骨损失提供了潜在的治疗标.

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