致命的感染不同地涉及单个肺移植接受者的全移植和本土肺部
Julian A Villalba1, E Heidi Cheek-Norgan1, Tucker F Johnson2
1From the Departments of Laboratory Medicine and Pathology (Villalba, Cheek-Norgan, Yi, Boland, Aubry, Roden).
Archives of pathology & laboratory medicine
|September 27, 2023
概括
呼吸道感染对肺移植接受者有不同的影响. 在单个肺移植接受者中,全移植肺部的感染严重程度高于本土肺部,这表明灵敏度不同,并告知患者管理.
科学领域:
- 肺部病理学 肺部病理学
- 移植手术 移植手术
- 传染性疾病 传染性疾病
背景情况:
- 呼吸道感染是肺移植后的一个主要并发症.
- 与本地肺相比,肺异体移植可能表现出不同的感染易感性.
- 这可能导致单个肺移植接受者 (SLTRs) 的疾病严重程度变化.
研究的目的:
- 在SLTRs中调查异位感染对异位移植与本地肺部的影响.
- 为了比较SLTRs中的感染模式与双重肺移植接受者 (DLTRs) 的感染模式.
主要方法:
- 对肺移植接受者 (LTR) 的医疗记录和胸部CT扫描进行系统审查.
- 组织病理学特征被分析为每一个肺叶,并分级.
- 计算和比较SLTRs和DLTRs之间的多杆菌病理学得分 (MLHS) 和双边比率 (MLHSratio).
主要成果:
- 在SLTR中,异位移植显示出更高的感染严重程度 (MLHSA异位移植>MLHSNative,P = .02).
- 原生肺叶通常不参与SLTRs,与DLTRs不同的是,所有叶子都受到影响.
- CT扫描显示了所有DLTR的双边感染模式,但仅在6个SLTR中的2个中.
结论:
- 所有移植和本地肺部表现出对呼吸道感染的明显易感性.
- 这些发现对于优化肺移植接受者的临床管理至关重要.
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