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Updated: Jun 9, 2026

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乳腺癌肺转移的空间和时间映射确定TREM2巨细胞作为转移边界的调节者

Ido Yofe1, Tamar Shami2, Noam Cohen2

  • 1Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.

Cancer discovery
|September 27, 2023
PubMed
概括

转移性复发导致癌症死亡. 这项研究揭示了TREM2+调节性巨细胞在侵袭边缘创建免疫抑制,阻碍癌症免疫疗法. 准这些髓状细胞可以改善治疗方法.

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相关概念视频

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...