基于注意力的生成对抗网络改善了从多式联络数据中预测癌症的预后结果
Mingguang Shi1, Xuefeng Li1, Mingna Li1
1School of Electrical Engineering and Automation, Hefei University of Technology, Hefei, Anhui 230009, China.
Briefings in bioinformatics
|September 27, 2023
概括
本研究介绍了CSAM-GAN,这是一种深度学习方法,用于使用多式联络数据预测癌症预后结果. 它有效地整合和选择特征,改善癌症分层和个性化医疗.
科学领域:
- 在瘤学瘤学.
- 生物信息学是一种生物信息学.
- 人工智能的人工智能
背景情况:
- 预测预后结果对于癌症治疗和个性化医学至关重要.
- 癌症数据的异质性和多样性给数据整合和特征选择带来了挑战.
- 准确的预后分层需要先进的方法来处理多式联运数据.
研究的目的:
- 开发一种新的深度学习方法,用于多模式癌症数据集成和特征选择.
- 为了提高预后结果预测和癌症分层的准确性.
- 为应对异质多式模式癌症数据所带来的挑战.
主要方法:
- 提出了一个深度学习方法,CSAM-GAN (顺序通道-空间注意模块-生成对抗网络).
- 使用了连续的通道空间注意模块与编码器-解码器用于功能改进.
- 采用对抗式学习的区分器网络,从多种数据模式中捕获复杂的异质信息.
主要成果:
- CSAM-GAN有效地整合并从多式癌症数据 (miRNA,mRNA,组织病理学) 中选择了特征.
- 与深度神经网络 (DNN) 分类器相结合的CSAM-GAN在较低级别质瘤和脏清细胞癌数据集上表现优于基线方法.
- 在预后分层任务中表现卓越.
结论:
- 在癌症预后中,CSAM-GAN为多式联络数据集成和特征选择提供了有效的解决方案.
- 这种方法弥合了异质数据和准确的预后结果预测之间的差距.
- 该方法对推进个性化癌症医学和治疗开发具有前景.
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