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估计毛囊淋巴瘤患者的终身治疗负担:使用现实世界多中心数据的回顾性研究

Aino Rajamäki¹, Mika Hujo², Reijo Sund¹

¹Institute of Clinical Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.

JCO clinical cancer informatics

|September 27, 2023

概括

大多数毛囊淋巴瘤患者在一生中需要多个治疗线. 一个20年的模拟显示,大约三分之二的患者接受至少两种疗法,三分之一需要三种或更多.

科学领域:

血液学血液学血液学
在瘤学瘤学.
卫生经济学卫生经济学

背景情况:

毛囊性淋巴瘤 (FL) 有一个长期的过程与频繁的复发.
关于FL患者获得的累计治疗线数量的数据有限.
准确的数据对于对FL治疗的健康经济评估至关重要.

研究的目的:

为了建模毛囊淋巴瘤患者的终身治疗负担.
通过使用现实世界的数据,估计了在20年内接受的治疗线数.

主要方法:

进行了20年的模拟,使用743名FL患者的回顾性多中心数据.
使用与韦布尔分布竞争的风险模型来模拟状态过渡.
用数据归算和1000次重复来确保可靠性.

主要成果:

20年来,97%的患者接受了第一线治疗.
66%的患者接受了二线治疗,34%的患者接受了三线治疗,15%的患者接受了四线治疗.
每名患者的中位数治疗线是2.

结论:

毛囊性淋巴瘤患者通常需要多种疗法.
大约三分之二的患者接受至少两种线路治疗,三分之一的患者接受至少三种线路治疗.
这些发现凸显了FL的大量累积治疗负担.

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