穿皮冠状动脉干预后的吸烟和心血管结果:一项韩国研究
You-Jeong Ki1, Kyungdo Han2, Hyo-Soo Kim3,4
1Cardiovascular Center, Uijeongbu Eulji Medical Center, Uijeongbu-si, Gyeonggi-do, Republic of Korea.
European heart journal
|September 27, 2023
概括
穿皮冠状动脉干预 (PCI) 后吸烟显著增加了不良心血管事件. 然而,在PCI后暴露20包年 (PYs) 之前戒烟提供了与非吸烟者相似的结果.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 戒烟的研究 戒烟的研究
背景情况:
- 吸烟是心血管疾病的主要危险因素.
- 穿皮冠状动脉干预 (PCI) 是一种常见的治疗冠状动脉疾病的程序.
- 吸烟状态和戒烟对PCI后结果的影响需要进一步调查.
研究的目的:
- 调查PCI后吸烟状态和心血管结果之间的关联.
- 评估戒烟对接受PCI的患者主要心血管和脑血管不良事件 (MACCE) 的影响.
- 为了确定吸烟暴露的数量是否会影响戒烟的好处.
主要方法:
- 通过使用韩国国家医疗保险系统数据,分析了全国74,471名接受PCI (2009-2016) 的患者队列.
- 根据PCI后的健康检查,患者被分为非吸烟者,前吸烟者和目前吸烟者.
- 研究对比了主要心血管和脑血管不良事件 (MACCE) 的发生率,重点关注31887名患者的抽烟戒烟效应,这些患者的PCI前后数据.
主要成果:
- 与非吸烟者相比,目前吸烟者的MACCE风险比非吸烟者的风险高19.8% (aHR 1.198).
- 前吸烟者MACCE率与非吸烟者相当 (aHR为1.036).
- 在PCI后戒烟的患者中,累计暴露不到20包年 (PYs) 的患者的结果与持久的非吸烟者相似. 然而,戒烟者≥20个PY的风险与持续吸烟者的风险相当.
结论:
- 吸烟与接受PCI的患者的不良结果增加有关.
- 在PCI后戒烟,特别是少于20包年暴露,与心血管风险相关,与非吸烟者的风险相美.
- 早期戒烟对于改善PCI后心血管结果至关重要.
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