对于直肠癌的短期放射治疗后,手术的最佳时间是什么?

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Solomon-Miles Donnelly¹, James Wyatt², Simon G Powell²

¹The University of Liverpool, L69 3BX, United Kingdom.

Surgical oncology

|September 27, 2023

概括

对于直肠癌的短期新辅助放射治疗后手术的最佳时间尚不清楚. 延迟手术可能会减少并发症,但可能会增加局部复发,没有明显的影响生存观察到.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
辐射瘤学辐射瘤学

背景情况:

短期的新辅助放射治疗是用于直肠癌的治疗,改善了局部复发率.
放射治疗后的最佳手术时间缺乏共识,因为证据有限且相互矛盾.
关于放射治疗和直肠癌手术之间的间隔,临床实践存在变化.

研究的目的:

综合当前关于短期新辅助放射治疗和直肠癌手术之间的最佳时间间隔的证据.
评估不同外科手术时间对瘤和术后结果的影响.

主要方法:

在PubMed和Embase数据库 (1980-2023) 中进行了全面的文献搜索.
包括随机对照试验,大型观察研究和对直肠癌短期术前放射治疗的系统审查.
主要结局评估包括整体存活率,无病存活率和术后并发症.

主要成果:

延迟手术 (超过四周) 显示瘤下降阶段增加,术后并发症减少.
最近的数据表明,随着手术延迟,局部复发率可能会增加.
对比不同手术间隔的研究没有证明对整体存活率有重大影响.

结论:

对直肠癌的短疗程新辅助放射治疗后的最佳手术时间是复杂的,尚未确定.
现有的高质量证据有限,需要进一步研究.
未来的研究应该着重于澄清各种手术间隔的风险和益处,以优化治疗策略.

关键词:

这是直肠癌.短时间的放射疗法.

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