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Updated: Jul 15, 2025

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody mAb by Neutralizing TNF Using an In Vitro Bioanalytical Method
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在人体单细胞中,TNFα通过NOX2-Lyn-SHP-1轴对抗interleukin-10抗炎途径

Marwa Ben-Khemis1, Dan Liu1, Coralie Pintard1

  • 1INSERM U1149, CNRS ERL8252, Centre de Recherche sur l'Inflammation, Université Paris-Cité, Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Paris, F-75018, France.

Redox biology
|September 27, 2023
PubMed
概括

瘤坏死因子-α (TNFα) 通过NOX2-ROS-Lyn-SHP1通路阻断单细胞中的英尔路金-10 (IL-10) 抗炎作用,阻碍炎症解消. 在小鼠中,SHP1/2抑制恢复了IL-10信号传递,并防止了关节炎.

关键词:
在 IL-10 中,IL-10 是 IL-10 的代表.炎症 炎症是一种炎症.单细胞 (Monocytes) 是一种单细胞.氧二氧化 (NOX2) 是一种有反应性氧物种的反应性氧物种.这就是TNFα.

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