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了解黄热病相关的心肌损伤:一项解剖研究

Fernando Rabioglio Giugni¹, Vera Demarchi Aiello², Caroline Silverio Faria³

¹Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil; Instituto do Coração InCor, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

|September 27, 2023

概括

严重的黄热病 (YF) 经常通过直接的病毒攻击,内皮损伤和炎症引起心脏损伤,干扰素马诱导蛋白10 (IP-10) 可能发挥关键作用.

科学领域:

病毒学病毒学
病理学病理学病理学
心脏病学心脏病学

背景情况:

黄热病 (YF) 是一种流行于南美和非洲的病毒性出血性发烧.
在YF中心肌损伤的发病原因尚不清楚.
这项研究调查了致命的YF病例中的心脏病理.

研究的目的:

在致命的黄热病例中评估心脏病理.
为了阐明YF心肌损伤的机制.
为了确定潜在的心脏参与的生物标志物.

主要方法:

对2017-2019圣保罗流行病中致命的YF病例的回顾性解剖研究.
组织病理学评估,电子显微镜和心脏组织的免疫组织化学.
炎症和内皮细胞生物标志物的YFV-RNA和蛋白质组学分析的RT-qPCR.

主要成果:

心肌纤维化 (93.2%),心肌细胞缩 (93.2%) 和内皮细胞变化 (91.8%) 是常见的.
在12.3%的病例中观察到病毒性心肌炎;与疫苗相关的YF也显示出心肌炎.
在95.7%的心脏样本中检测到YFV-RNA;发现炎症生物标志物增加,包括IP-10.

结论:

心肌损伤在严重的YF中很常见,由多因素机制引起.
直接的YFV损伤,内皮损伤和炎症反应有助于心脏病理.
干扰素马诱导蛋白10 (IP-10) 可能在YF相关的心肌损伤中起着突出作用.

关键词:

17DDDD 17DDDD 17DDDD 17DDDD 17DD 17DD 17DD 17DD 17DD 17DD 17DD 17DD 17DD 17DD 尸体解剖是可以做的.化学因子化学因子化学因子细胞因子 (cytokines) 是一种细胞因子.心脏导电系统的心脏导电系统 IP-10 标签:IP-10 标签:IP-10 标签:IP-10 标签:IP-10 标签:IP-10 标签:IP-10 肌心炎是一种心肌炎.血管内皮质的血管内皮.在YEL-AVD中,YEL-AVD是最重要的.黄热病黄热病是什么

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