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Updated: Jul 15, 2025

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通过RNA-98-5p,IL-7通过准CDKN1AA来促进CD19导向的CAR-T细胞的增殖

Li-Rong Yang1, Lin Li2, Ming-Yao Meng2

  • 1Central Laboratory of Yan'an Hospital Affiliated to Kunming Medical University, China; Key Laboratory of Tumor Immunological Prevention and Treatment, Yunnan Province, China; Department of Oncology, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, China.

International immunopharmacology
|September 27, 2023
PubMed
概括

介质素-7 (IL-7) 增强了对CD19+癌症的仿真抗原受体T细胞 (CAR-T) 增殖. 这通过miRNA-98-5p针对CDKN1A发生,从而提高了CAR-T疗法的疗效.

关键词:
针对CD19的CAR-T细胞.这就是CDKN1A.在IL-7中,IL-7是最常见的.免疫治疗是一种免疫疗法.微RNA-98-5p是一种小RNA.

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