多在高脂肪诱导的肥胖小鼠中通过调节脂质基因表达来产生抗肥胖作用
Yuyang Ye1, Yuya Kawaguchi1, Asahi Takeuchi1
1Faculty of Applied Biological Sciences, Department of Applied Life Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Nutrition research (New York, N.Y.)
|September 27, 2023
概括
多 (ROSE) 在食高脂肪饮食的小鼠中显著降低了体重增加和改善了脂质代谢. 这些发现表明,ROSE作为一种潜在的天然化合物,可以对抗肥胖和相关的代谢障碍.
科学领域:
- 营养科学 营养科学
- 代谢健康 代谢健康
- 药理学 药理学是指药理学的学科.
背景情况:
- 肥胖是心血管疾病的重要危险因素.
- 聚醇在预防代谢性疾病方面表现有前途.
- 多对脂质代谢和肥胖的特定影响需要研究.
研究的目的:
- 为了研究多 (ROSE) 的抗肥胖作用.
- 为了确定ROSE对小鼠脂质代谢的影响.
- 阐明 ROSE 行动的基本机制.
主要方法:
- C57BL/6J小鼠被养高脂肪饮食,并补充了0.25%的ROSE,持续35天.
- 测量了体重,脂肪组织体重,血清胆固醇和肝脏甘油三水平.
- 分析了与肝脏和脂肪组织中的脂质代谢相关的基因和蛋白质表达.
- 用液体染色学-并联质谱法量化多成分.
主要成果:
- 服用ROSE补充剂显著降低了体重增加和脂肪组织体重.
- 血清胆固醇和肝脏甘油三水平降低,而便甘油三水平增加.
- 下调节了肝脏中的关键脂质合成基因 (Scd1,Hmgcr,Acat1) 和蛋白质.
- 在白色脂肪组织中,ROSE 调高了与脂解相关的基因和蛋白质 (脂肪三糖 lipase,激素敏感 lipase,过氧体乙烯酸酶 A 氧化酶 1).
- 埃拉基酸被确定为ROSE中最丰富的多,可能有助于其抗肥胖作用.
结论:
- 多显示出显著的抗肥胖作用.
- 罗斯通过促进脂解和抑制脂合成来改善脂代谢.
- 多中的酸是这些有益作用的关键成分.
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