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上腺切除术后发生术后并发症的危险因素:多中心队列研究
Alessandro Parente1,2, Sivesh K Kamarajah1,3, Joseph P Thompson1
1HPB Surgery Unit, Queen Elizabeth Hospital, Birmingham, UK.
上腺切除术用于染细胞瘤的死亡率很低,但并发症很常见. 并发症和手术方法显著增加并发症和长时间住院的风险,这对于患者咨询至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 手术瘤学手术瘤学
- 临床结果研究研究
背景情况:
- 染细胞瘤是一种神经内分泌瘤,需要进行手术切除 (腺切除术).
- 手术后的并发症和延长的住院时间是上腺切除术后的重大问题.
研究的目的:
- 为了确定术后并发症的发生率.
- 为了确定因发红细胞瘤而进行上腺切除术后与并发症和长时间住院相关的风险因素.
主要方法:
- 一项多中心研究评估了406名因发红细胞瘤而接受上腺切除术的患者 (2012-2020年).
- 数据包括人口统计,外科手术期间的结果和并发症 (Clavien-Dindo分类).
- 多变量模型评估了并发症和住院时间的风险因素.
主要成果:
- 该研究在109名患者中记录了148例并发症 (26.8%);术后死亡发生在0.5%的患者中.
- 有关并发症的独立风险因素包括高并发症指数,从腹腔镜转换为开放手术,以及开放手术.
- 长时间住院 (≥5天) 与高并发症指数,较大的瘤大小和开放式手术方法有关.
结论:
- 上腺切除术治疗染细胞瘤的死亡率很低,但术后并发症的发生率很高.
- 患者的并发症和选择的外科手术方法 (腹腔镜 vs 开放) 是不良结果和延长住院的关键预测因素.
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