具有不同认知功能状态的系统性红斑狼患者的功能性大脑网络变化:图形理论分析研究研究
Xiaolu Li1, Jianguo Xia2, Jianfeng Hu2
1From the Department of Radiology, Graduate School of Dalian Medical University, Dalian.
Journal of computer assisted tomography
|September 27, 2023
概括
系统性红斑狼 (SLE) 患有较低认知功能的患者表现出与临床标志物相关的大脑网络受损. 这些网络变化可以作为成像标志物来监测SLE进展和认知变化.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 免疫学 免疫学 免疫学
背景情况:
- 系统性红斑狼 (SLE) 是一种自身免疫性疾病,可以影响中枢神经系统,导致认知障碍.
- 了解SLE认知功能障碍的神经生物学基础对于有效管理至关重要.
研究的目的:
- 通过使用图形理论分析,研究SLE患者的不同认知功能的大脑功能网络干扰.
- 探索这些网络变化,临床数据和神经精神病学尺度之间的关系.
主要方法:
- 在38名女性SLE患者和44名健康对照中使用图形理论分析休息状态fMRI数据.
- 根据MoCA得分,SLE患者被分为高 (MoCA≥26) 和低 (MoCA<26) 认知功能组.
- 全球和本地网络拓性质的比较,然后在低MoCA组中与临床指标进行相关性分析.
主要成果:
- 与对照组相比,低MoCA分数的SLE患者表现出改变的全球网络特性,包括增加特征路径长度和降低全球/本地效率.
- 局部网络分析显示,在低MoCA组中,特定大脑区域 (例如前环膜,门,皮,Heschl gyrus) 的节点效率下降.
- 低MoCA组的网络变化与C4水平,疾病持续时间和IgM水平等临床标志物相关.
结论:
- 功能性大脑网络拓学的破坏与SLE患者的认知障碍有关.
- 在SLE中改变的大脑网络特性可能作为监测疾病进展和认知状态的潜在成像生物标志物.
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