成功治疗多药耐药结核病而没有艾滋病病毒抑制:错过的机会
Keri Geiger1,2, Amita Patil2, Chakra Budhathoki1
1Johns Hopkins University School of Nursing, Baltimore, MD.
Journal of acquired immune deficiency syndromes (1999)
|September 27, 2023
概括
与多抗药结核病 (MDR-TB) 和艾滋病毒的同时感染是常见的. 成功的MDR-TB治疗与HIV病毒抑制有关,特别是当ART疗法没有切换到蛋白酶抑制剂时.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 与多抗药结核病 (MDR-TB) 和艾滋病毒的同时感染很普遍.
- 关于MDR-TB治疗如何影响艾滋病毒疾病指标的研究有限.
研究的目的:
- 在成功完成了MDR-TB治疗的HIV感染者 (PWH) 中调查与HIV病毒抑制相关的因素.
- 在MDR-TB治疗结束时确定HIV病毒抑制的相关性.
主要方法:
- 对PWH进行了回顾性队列研究,并取得了成功的MDR-TB治疗结果.
- 用多变量回归模型来分析数据.
- 探索了人口,临床因素和艾滋病毒病毒抑制之间的关联.
主要成果:
- 在531名PWH中,74.4%的人实现了病毒抑制.
- 年龄较大与病毒抑制的可能性增加有关.
- 以前的结核病,在MDR-TB启动时可检测的病毒载量,居住在乡镇,以及特定抗逆转录病毒疗法 (ART) 的变化 (切换到蛋白酶抑制剂或不改变贝达基林) 与病毒抑制的几率较低有关.
结论:
- 增加的药片负担和不良反应并没有显著影响HIV病毒抑制.
- 将ART转换为蛋白酶抑制剂或在服用贝达奎林时不保持ART变化与较低的病毒抑制有关.
- 在改变ART疗法时,患有MDR-TB的PWH可能需要额外的支持.
相关概念视频
Pulmonary Tuberculosis V
194
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
194
Retrovirus Life Cycles
46.1K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
46.1K
Pulmonary Tuberculosis I
257
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
257
Pulmonary Tuberculosis IV
157
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
157
Pulmonary Tuberculosis II
256
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
256
Pulmonary Tuberculosis III
357
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
357


