神经炎症与帕金森病中痴呆风险有关
Antonina Kouli1, Lennart R B Spindler1, Tim D Fryer1,2
1Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0PY, UK.
Brain : a journal of neurology
|September 27, 2023
概括
神经炎症,而不是tau,与早期帕金森病 (PD) 的痴呆风险有关. 高风险患者中神经炎症的增加表明,它是预防PD痴呆症 (PDD) 的关键因素.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 帕金森病 (PD) 经常导致痴呆症 (PDD),在10年内影响近一半的患者.
- 了解驱动PDD的机制对于开发预防或减缓认知衰退的疗法至关重要.
- 神经炎症和tau积累与神经退行有关,但它们在PDD中的早期作用尚不清楚.
研究的目的:
- 为了研究神经炎症和陶蛋白积累在早期帕金森病患者和不同痴呆风险患者中所起的作用.
- 为了确定这些病理是否先于显著的认知衰退,并预测PDD的发展.
主要方法:
- 使用PET神经成像11C-PK11195 (神经炎症) 和18F-AV-1451 (tau) 在早期PD患者中,根据痴呆风险分层 (NET-PDD研究).
- 在高风险,低风险PD组和对照组之间,在43个大脑区域中比较了标志物结合潜力 (BPND).
- 分析了BPND,认知表现 (ACE-III) 和血清炎症标志物之间的关联.
主要成果:
- 与对照组和低风险组相比,在高痴呆风险组的皮质下和皮质区域发现显著增加的神经炎症 (11C-PK11195 BPND).
- 神经炎症与较差的认知表现和较高的血清促炎细胞因子相关.
- 积 (18F-AV-1451) 是最小的,与认知无关;然而,PD参与者中区域神经炎症和相关,特别是在高风险组中.
结论:
- 在PD早期显著的区域神经炎症与发展PDD的更高风险有关.
- 神经炎症似乎是PDD发展的关键早期病理因素.
- 通过免疫调节策略向神经炎症可能提供一种治疗方法,以预防或减缓PDD的进展.
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