社区贫困和神经管缺陷
Shannon Pruitt Evans1,2, Elizabeth C Ailes1, Michael R Kramer3
1From the Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA.
Epidemiology (Cambridge, Mass.)
|September 27, 2023
概括
邻居的社会经济地位 (SES) 与神经管缺陷 (NTDs) 的更高风险有关. 在这项研究中,更高的社区贫困,特别是脊柱裂,与增加NTD风险有关.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 个人社会经济地位 (SES) 与神经管缺陷 (NTD) 风险有关.
- 社区SES和NTD风险之间的关联仍未得到充分研究.
研究的目的:
- 调查人口普查区社会经济地位 (SES) 措施与NTD风险之间的关联.
- 为了确定社区层面的SES是否影响NTD风险.
主要方法:
- 利用了来自国家出生缺陷预防研究 (NBDPS,1997-2011) 的数据.
- 将母亲的地址与人口普查区联系起来,SES测量以计算邻里贫困指数.
- 采用了概括估计方程来分析邻居贫困四分位数对NTD风险的影响,并对共变量进行调整.
主要成果:
- 较高的社区贫困四分位数与NTD风险增加有关.
- 特定的NTD如脊椎裂显示出类似的关联,而无脑症和脑估计被减弱.
- 关联因母亲的种族种族而异.
结论:
- 居住在社会经济上处于贫困的人口普查区与NTD的风险更高有关.
- 这些发现突显了邻居层面因素在NTD病因学中的重要性,特别是在脊椎分裂症.
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