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腹部海马体向下边皮层和底侧杏仁体的投射被环境恐惧和灭绝回忆差异性激活
Emma T Brockway1, Sarah Simon1, Michael R Drew1
1Center for Learning and Memory, Department of Neuroscience, University of Texas at Austin, Austin, TX, USA.
Neurobiology of learning and memory
|September 27, 2023
概括
独特的海马体记忆路径控制恐惧和灭绝行为. 恐惧回忆激活了腹部海马体 (vHPC) 投射到底侧杏仁体 (BLA),而灭绝回忆激活了vHPC投射到下边皮层 (IL).
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 记忆研究 记忆研究
背景情况:
- 海马对于形成上下文恐惧和灭绝记忆至关重要.
- 有不同的神经回路被假设为这些相互竞争的记忆表征的基础.
- 这些海马体表现如何影响行为仍然不太清楚.
研究的目的:
- 为了研究腹腔海马体 (vHPC) 投射到内膜皮层 (IL) 和底侧杏仁体 (BLA) 在恐惧和灭绝记忆回忆期间如何差异激活.
- 阐明特定的vHPC投影路径在编排适当的行为反应中的作用.
主要方法:
- 使用的霍乱毒素B子单元用于向IL和BLA投射的vHPC神经元的逆标签.
- 量化c-Fos立即早期的基因表达,以测量在恐惧回忆和灭绝回忆之后的神经元活动.
- 包括对照实验,以区分特定学习活动与背景暴露效应.
主要成果:
- 恐惧回忆增加了c-Fos表达在vHPC投影到BLA.
- 灭绝回忆增加了对IL的vHPC预测中的c-Fos表达.
- 不同的激活模式证实了基于记忆类型的选择性途径参与.
结论:
- 海马的上下文恐惧和灭绝记忆差异地激活了不同的vHPC投影通路 (到IL和BLA).
- 这些发现表明,选择性激活海马体投影通路是编排适合上下文行为的关键机制.
- 这提供了对恐惧和灭绝记忆表达的神经基础的洞察.
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